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Pfander, Boris

Dr. Boris Pfander

Otto-Hahn Research Group on DNA Replication & Genome Integrity, Max-Planck-Institute of Biochemistry

Responsibilities

Project A23: Chromatin as limiting factor in the regulation of DNA repair pathway choice

Contact

Max-Planck Institute of Biochemistry
Am Klopferspitz 18
82152 Martinsried
GERMANY

Phone: +49 (0)89 85783050
Fax: +49 (0)89 85783022

Website: http://www.biochem.mpg.de/pfander

Work group

Project A23

Curriculum Vitae

Academic Education

  • 2000 Diploma in Biochemistry, University of Hannover & Hannover Medical School, Germany. Thesis on “Characterization of NGF-induced phosphorylation of endocytotic proteins in PC12-cells“, Supervisor: Dr. Rudolf Bauerfeind

Advanced Professional Degrees

  • 2005 PhD in Biology, Ludwig-Maximilians University Munich, Germany & Max-Planck Institute of Biochemistry, Martinsried, Germany; Thesis: “Regulation of genome stability by SUMO- and ubiquitin-modification of PCNA“

Positions held

  • since 2010 Research Group leader (Otto-Hahn Research Group, W2) Max-Planck Institute of Biochemistry, Martinsried, Germany 
  • 2006- 2010 Postdoctoral work at London Research Institute, CRUK, South Mimms, UK, Chromosome Replication Lab (Prof. John Diffley) 
  • 2005- 2006 Postdoctoral work at the Max Planck Institute of Biochemistry, Martinsried, Germany, Dept. of Molecular Cell Biology (Prof. Stefan Jentsch) 
  • 2001-2005 PhD work at the Max Planck Institute of Biochemistry, Martinsried, Germany, Dept. of Molecular Cell Biology (Prof. Stefan Jentsch)

Honors and Awards

  • 2007- 2010 Human Frontier Science Program Long Term Fellowship 
  • 2007 EMBO Long Term Fellowship
  • 2006 - 2010 Cancer Research UK Research Fellowship
  • 2006 Otto-Hahn Award (Opportunity to start an independent Junior Research Group – Max-Planck Society, Germany) 
  • 2006 Otto-Hahn Medal (Max-Planck Society, Germany) 
  • 2006 MPIB Junior Research Award (Max-Planck Institute of Biochemistry, Martinsried, Germany)

Other professional activities

  • since 2016 Treasurer and elected Board Member, German Society of DNA Repair Research (DGDR)
  • 2016 Elected Representative of Research Group Leaders (Max Planck Institute of Biochemistry)
  • 2016 member of the organizing committee of the conference “DNA Repair”, Essen, Germany
  • 2014-2016 member of the Advisory Board, German Society of DNA Repair Research (DGDR)
  • since 2014 External member of PhD examination boards and thesis advisory committees at ETH Zürich, Switzerland; University of Ulm; LMU Munich
  • since 2011 Reviewer for >10 scientific journals
  • since 2011 Reviewer for funding agencies (German Research Council (DFG), Max Planck Society, Medical Research Council, UK, Swiss National Science Foundation, Wellcome Trust, UK)
  • since 2010 Junior Faculty Member - International Max Planck Research School (IMPRS) „From Biology to Medicine‟


Selected CRC project-releated publications

Reusswig, K. U., Zimmermann, F., Galanti, L. and Pfander, B. (2016). Robust replication control is generated by temporal gaps between licensing and firing phases and depends on degradation of firing factor Sld2. Cell Rep.17, 556-569.

Lee, S. H., Princz, L. N., Klügel, M. F., Habermann, B., Pfander, B., and Biertümpfel, C. (2015). Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage. eLife. e12256

Gritenaite, D., Princz, L. N., Szakal, B., Bantele, S. C. S, Wendeler, L., Schilbach, S., Habermann, B. H., Matos, J., Lisby, M., Branzei, D. and Pfander, B. (2014). A cell cycleregulated Slx4-Dpb11 signalling complex controls the resolution of DNA repair intermediates linked to stalled replication. Genes Dev. 28:1604-1619

Pfander, B., and Diffley, J. F. X. (2011). Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J. 30:4897-907

Parnas, O., Zipin-Roitman, A., Pfander, B., Liefshitz, B., Mazor Y., Ben-Aroya, S., Jentsch, S., and Kupiec, M. (2010). Elg1, an alternative subunit of the RF-C clamploader, preferentially interacts with SUMOylated PCNA. EMBO J. 29, 2611-2622