Pioneers conquer core histones at the chromatin frontier
Nature Structural & Molecular Biology News & Views on chromatin accessibility, with authors Magdalena Murawska, Andreas Ladurner and Carla Margulies
10.08.2023
Magdalena Murawska, Andreas G. Ladurner & Carla E. Margulies (2023 Aug 10) Pioneers conquer core histones at the chromatin frontier. Nature Structural & Molecular Biology 30, 1050-1053. https://doi.org/10.1038/s41594-023-01058-9
Summary cited from the article:
Pioneer transcription factors access gene regulatory sites embedded within chromatin. They drive gene expression programs vital for cell fate decisions and cellular reprogramming, but how they engage nucleosomal sites at the molecular level is unclear. New results show that they engage histones and collaborate to overcome the nucleosome barrier.