A25 - Role of the nuclear membrane protein Lem2 in silencing and genome surveillance
We recently demonstrated that the conserved integral membrane protein Lem2 controls the localization and silencing of heterochromatin at the nuclear periphery (Barrales et al., Genes Dev 2016). Intriguingly, this repressive function of Lem2 is not restricted to constitutive heterochromatin domains. Using genomic and biochemical approaches, we aim to dissect the underlying pathways and to unveil the molecular mechanisms by which Lem2 mediates repression of these different substrates.
Prof. Dr. Sigurd BraunProjektleiter, Institute for Genetics, Justus-Liebig-Universität Gießen +49 (0)641-99-35473 |