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Cell-to-Cell Heterogeneity in Chromatin Structure

Mini-symposium on September 21, 2018 in the BMC


Cell-to-cell variability in cell populations permits adaptation to different environmental challenges. How heterogeneity is controlled at the chromatin level is largely unknown. This mini-symposium brings together experts in chromatin research and single-cell methods to develop new approaches to deconvolute dynamics and heterogeneity in chromatin structure in various systems.

Date: Friday, September 21, 2018
Time: 14:00 - 18:00
Venue: Small Lecture Hall (N02.040), Biomedical Center (BMC), Munich

Organizers: Sigurd Braun and Nicolai Siegel

Invited Speakers:
Bassem Al-Sady San Francisco, Richard Bartfai Nijmegen, Magda Bienko Stockholm, Maria Colomé-Tatché Munich, Jane Mellor Oxford, Robert Schneider Munich, Angela Taddei Paris

Open to the scientific community: undergrad students, doctoral candidates, postdocs and all scientists.

download poster (pdf, 865 KB)

download program: (pdf, 453 KB)

14:00 Welcome

14:10 Jane Mellor, University Oxford
From smRNA FISH to a mathematical model for gene expression: How antisense transcription modulates chromatin structure to alter rates of transcription elongation and transcript stability

14:32 Robert Schneider, Helmholtz Zentrum Munich
Regulation of gene induction and repression in individual cells

14:54 Nicolai Siegel, Munich
What controls heterogeneity in antigen expression?

15:16 Magda Bienko, Karolinska Institute Stockholm
Illuminating genome organization through integrated microscopy and sequencing

15:38 Richard Bartfai, University Nijmegen
The dark side of the Plasmodium chromatin

16:00 Coffee Break

16:30 Maria Colomé-Tatché, Helmholtz Zentrum Munich
(Single Cell) computational epigenomics

16:52 Sigurd Braun, LMU Munich
Regulators of silent chromatin

17:14 Bassem Al-Sady, UCSF, San Francisco
Dynamic single cell measurements in fission yeast unmask instability in the heterochromatin spreading reaction

17:36 Angela Taddei, Curie Institute Paris
Nuclear Dynamics upon quiescence entry and return to growth

18:00 Reception with Brezn & Beer