News & Highlights

• 

  26.05.2025 – 27.05.2025

  Join us for Chromatin Days – May 26-27, 2025

  Reunion and Valediction – celebrating 12 years of exciting chromatin research in Munich more
• 

  09.04.2025 – 11.04.2025

  Paris-Munich Epigenetics Workshop & Symposium 2025

  Resgistration is open! more
• 

  03.04.2025 – 04.04.2025

  interact 2025 – Our Collective Impact

  Student-led conference – sign up now for a poster or talk more
• 

  13.03.2025

  Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory

  Stem Cell Reports article from the Hörmanseder lab, with collaborations from the Hamperl and Scialdone labs more
• 

  12.03.2025

  3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development

  bioRxiv preprint from the lab of associate member Boyan Bonev more
• 

  12.03.2025

  Genomic determinants of antigen expression hierarchy in African trypanosomes

  Nature article from the Siegel lab, with first author IRTG member Zhibek Keneskhanova and collaboration with Maria Colomé-Tatché more
• 

  28.02.2025

  Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery

  Nucleic Acids Research article from the Hamperl lab more
• 

  20.02.2025

  Cellular responses to RNA damage

  Cell Review article from the Stingele Lab more
• 

  13.02.2025

  IRTG member Jie Hua (AG Imhof) slams for science!

  CAS Science Slam "Mystery of Reproduction" at the Mensch und Natur Museum in Nymphenburg more
• 

  11.02.2025 – 13.03.2025

  STEM PASSION: A journey inspired by women in science

  Helmholtz Munich exhibition opening and networking event more
• 

  11.02.2025

  Co-transcriptional splicing is delayed in the highly expressed thyroglobulin gene

  Journal of Cell Science article from the Solovei lab, with first author IRTG member Simon Ullrich more
• 

  29.01.2025

  Sleep research award goes to Maria Robles

  Project leader Maria Robles receives this year's ‘Outstanding Scientific Achievement Award’ from the Sleep Research Society (SRS) more
• 

  24.01.2025

  ‘Digital Reprogramming’ Decodes Epigenetic Barriers of Cell Fate Changes

  bioRxiv preprint from the Hörmanseder lab, with first author IRTG member Ana Janeva more
• 

  21.01.2025

  H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development

  bioRxiv preprint from the Hörmanseder lab more
• 

  20.01.2025

  An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development

  Cell article from the Torres-Padilla lab, with first author Marlies Oomen more
• 

  23.12.2024

  Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes

  Nature Communications article from the Siegel lab, with first author IRTG member Claudia Rabuffo more
• 

  17.12.2024

  Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers

  PNAS article from the Schotta lab more
• 

  12.12.2024

  FrozONE: quick cell nucleus enrichment for comprehensive proteomics analysis of frozen tissues

  Life Science Alliance article from the Robles lab, with first author IRTG member Lukas Huschet more
• 

  11.12.2024

  Maria Elena Torres-Padilla is awarded Leibniz Prize 2024

  Highest scientific honor from the German Research Foundation (DFG) more
• 

  03.12.2024

  Trailblazer Lecture with Shelley Berger (University of Pennsylvania)

  Co-hosted by the CRC 1064 and the BMC more
• 

  23.11.2024

  Stem Cells & Ethics

  Panel discussion at the Deutsches Museum with Stefan Stricker and Maria Elena Torres Padilla more
• 

  30.10.2024

  Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei

  Nature article from the Siegel lab more
• 

  28.10.2024

  G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism

  Nucleic Acids Research article with contributions from the Schotta lab more
• 

  23.10.2024

  Munich Epigenetics Spotlight 2024

  Register before Sept 30! Virtual meeting hosted by epigenetics@HMGU more
• 

  18.10.2024

  Context-dependent epigenome rewiring during neuronal differentiation

  bioRxiv preprint from the Imhof and Bonev labs more
• 

  09.10.2024 – 11.10.2024

  6th Munich International Chromatin Symposium – Chromatin Dynamics

  October 9-11, 2024 in the BMC Munich more
• 

  01.10.2024

  Biotech & Pharma Career Day 2024

  Meet biotech and pharma companies from the greater Munich area more
• 

  25.09.2024

  Diversity, Identity & Fate at Biomedical Frontiers

  Symposium on diversity in research and in the people who do the research – SAVE the DATE more
• 

  19.09.2024

  Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis

  Nature Cell Biology article from the Cabianca Lab more
• 

  05.09.2024

  PLK1-Mediated Phosphorylation Cascade Activates Mis18 Complex to Ensure Centromere Inheritance

  Science article from the JP Arulanandam lab more
• 

  04.09.2024

  Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States

  A commentary in Epigenomics from Bartke and colleagues more
• 

  19.08.2024

  Generation of densely labeled oligonucleotides for the detection of small genomic elements

  Cell Rep Methods article from the Leonhardt lab with first author Clemens Steinek more
• 

  09.08.2024

  Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).

  Blood Advances article with contributions from the Leonhardt lab more
• 

  02.08.2024

  Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins

  Review Article in EMBO Reports by Anne-Sophie Pepin and Robert Schneider more
• 

  30.07.2024

  The origin of septin ring size control in budding yeast

  BioRxiv preprint from the IFE-Munich and U Gothenburg more
• 

  25.07.2024

  Responsible Research 2024

  A campus-wide event for next-generation researchers more
• 

  22.07.2024

  Chromatin Day, July 22, 2024

  Our penultimate annual meeting more
• 

  12.07.2024

  Structural basis for Mis18 complex assembly and its implications for centromere maintenance

  EMBO Reports article from Assoc. JP Arulanandam's Lab more
• 

  09.07.2024

  Memory of Somatic Cell Identity Affects Specific Cell Differentiation Programs Upon Reprogramming In Vivo

  bioRXiv preprint from the Hörmanseder lab more
• 

  08.07.2024

  Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS

  Molecular & Cellular Proteomics article from the Imhof lab, with first author IRTG member Frederike Schäfer more
• 

  06.07.2024

  Soapbox Science Munich 2024

  Public outreach for women scientists – co-sponsored by the SFB 1064! more
• 

  02.07.2024

  Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

  Nature Neuroscience article from the Götz and Bonev labs with SFB 1064 PI collaborations more
• 

  26.06.2024

  Alumni Career Get-together

  Meet former IRTG members now in the workforce: Addie Müntzenberger, Andrea Storti, Thomas van Emden more
• 

  18.06.2024

  Electro-elution-based purification of covalent DNA–protein cross-links

  Nature Protocols article from the Stingele Lab more
• 

  10.06.2024

  Engineering an inducible leukemia-associated transcription factor enables large-scale ex vivo production of functional human phagocytes

  PNAS article with contributions from the Stricker Lab more
• 

  07.06.2024

  Nitin Phadnis: Genomic Conflicts and the Origins of Species

  Lecture in CAS-LMU Research Focus Series "The Evolution of Incompatibilities – Molecular Mechanisms of Speciation" chaired by Axel Imhof more
• 

  30.05.2024

  Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

  Nucleic Acids Research article from the Becker lab, first author IRTG member Muhunden Jayakrishnan more
• 

  21.05.2024

  Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing

  Article in Angewandte Chemie International with contribution from the Stricker Lab more
• 

  17.05.2024

  Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

  EMBO Journal article from the Stingele (A34) and Jackson labs more
• 

  16.05.2024

  asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers

  A computational follow up study with co-author Till Bartke addressing the question of combinatorial read out of chromatin modifications in SNAP data more
• 

  08.05.2024

  The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry

  eLife article from the Imhof lab more
• 

  28.04.2024

  Optimizing biomedical information retrieval with a keyword frequency-driven Prompt Enhancement Strategy

  Preprint in bioRxiv spearheaded by Wasim Aftab and Tobias Straub of the BMC Bioinformatics Core Facility (with contribution from Zivkos Apostolou/AG Becker) more
• 

  25.04.2024

  ISWI catalyzes nucleosome sliding in condensed nucleosome arrays

  Nature Structural & Molecular Biology article with first-author IRTG alumna Petra Vizjak (AG Müller-Planitz) more
• 

  18.04.2024 at 14:00 

  IRTG 1064 Open Science Forum

  Open for all! Exchange experience and identify issues in the context of the SFB 1064 Open Science Program more
• 

  17.04.2024

  Reprogramming Stars #15: Colliding Cellular Reprogramming Paths, an Interview with Prof. Dr. Stefan Stricker

  Carlos-Filip Pereira interviews Stefan Stricker for Cellular Reprogramming more
• 

  16.04.2024

  Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells

  JCB Report from the Torres-Padilla Lab more
• 

  10.04.2024

  Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB

  Nature Cell Biology article collaboration spearheaded by the Stingele lab more
• 

  25.03.2024

  Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1

  Nature Structural & Molecular Biology artivle from the Müller lab more
• 

  25.03.2024

  Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo

  Review article in EMBO Reports by Marlies Oomen and Maria-Elena Torres-Padilla more
• 

  22.03.2024

  High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes

  bioRxiV preprint from the Colomé-Tatché and Siegel labs more
• 

  21.03.2024

  Smoother: on-the-fly processing of interactome data using prefix sums

  Nucleic Acids Reserach article from the Siegel lab more
• 

  15.03.2024

  IRTG Retreat 2024

  March 13-15, 2024 in Schloss Ringberg, Rottach-Egern am Tegernsee more
• 

  15.03.2024

  Generation of densely labeled oligonucleotides for the detection of small genomic elements

  bioRXiv preprint from the Leonhardt lab more
• 

  06.03.2024

  Decoding chromatin states by proteomic profiling of nucleosome readers

  Nature article from the Bartke lab more
• 

  28.02.2024

  Sciencerely, a science communication YouTube channel, receives Silver Creator Award

  Creative team, headed by Clemens Steinek from the Leonhardt Lab, is recognized for subscriber milestone more
• 

  28.02.2024

  The influencers' era: how the environment shapes chromatin in 3D

  Review article from the Cabianca lab in Curren Opinion in Genetics & Development more
• 

  21.02.2024

  Maria Robles is awarded research grant from the Chan Zuckerberg Inititiative

  Collaborative project in Neurodegeneration Challenge Network more
• 

  20.02.2024

  Bioinformatics Day 2024

  A Bioinformatics networking event on the Munich Life Science Campus more
• 

  15.02.2024

  A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation

  BioRXiv preprint, first author IRTG member Abubakar Muhammad, from the Braun Lab more
• 

  11.12.2023

  Energy-driven genome regulation by ATP-dependent chromatin remodellers

  Comprehensive Nature Reviews Molecular Cell Biology article co-authored by Philpp Korber and Karl-Peter Hopfner more
• 

  23.11.2023

  A single fiber view of the nucleosome organization in eukaryotic chromatin

  Nucleic Acids Research Article from the Korber and Müller-Planitz labs more
• 

  10.11.2023

  RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

  Molecular Cell article from the Stingele lab - first author former IRTG member Shubo Zhao more
• 

  02.11.2023

  Disordered protein regions partner up the cBAF remodeler for a chromatin dance

  Molecular Cell Spotlight article from the Ladurner lab more
• 

  31.10.2023

  The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A

  Cell Reports report, a Ladurner lab collaboration more
• 

  20.10.2023

  Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency

  Nucleic Acids Research article from the Hamperl lab more
• 

  16.10.2023

  Munich Epigenetics Spotlight Meeting

  Register before September 15! more
• 

  13.10.2023

  Trailblazer Lecture with Xiaowei Zhuang

  Co-hosted by the CRC 1064 and the BMC more
• 

  12.10.2023 09:00  – 16:00 

  Biotech & Pharma Career Day 2023

  Meet biotech and pharma companies from the greater Munich area more
• 

  12.10.2023

  Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity

  Genes & Development article from the Torres-Padilla lab more
• 

  04.10.2023

  The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes

  News from the Solovei lab with first author IRTG member Simon Ullrich more
• 

  30.09.2023

  CRC 1064 International Symposium POSTER DESIGN COMPETITION

  Submit your idea for artwork by September 30, 2023! more
• 

  20.09.2023

  epiAneufinder identifies copy number alterations from single-cell ATAC-seq data

  Nature Communications article from Associate Maria Colomé-Tatché's lab more
• 

  19.09.2023

  The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity

  EMBO reports article from the Imhof lab more
• 

  05.09.2023

  Rodrigo Villaseñor is awarded ERC Starting Grant

  Associate member is recipient of a Starting Grant from the European Research Council (ERC) – one of the most prestigious research grants in Europe. more
• 

  31.08.2023

  DNA mimic foldamers affect chromatin composition and disturb cell cycle progression

  Nucleic Acids Research article from the Imhof lab, first author Vera Kleene more
• 

  10.08.2023

  Pioneers conquer core histones at the chromatin frontier

  Nature Structural & Molecular Biology News & Views on chromatin accessibility, with authors Magdalena Murawska, Andreas Ladurner and Carla Margulies more
• 

  07.08.2023 – 09.08.2023

  IRTG 1064 Retreat, August 7-9, 2023 at the Söllerhaus

  Intercultural Communication, Science Values and Team-Building more
• 

  31.07.2023

  Decoding the impact of nuclear organization on antigenic variation in parasites

  Nature Microbiology article from the Siegel lab, first author Anna Barcons-Simon more
• 

  31.07.2023

  A non-proteolytic release mechanism for HMCES-DNA-protein crosslinks

  EMBO Journal publication from the Stingele lab more
• 

  27.07.2023

  Chromatin Day, July 27, 2023

  Hear about exciting chromatin research in Munich more

• 22.07.2023

  Charlotte Blessing receives dissertation prize

  Former IRTG member and doctoral researcher in the Ladurner lab is awarded the Dr. Hildegard and Heinrich Fuchs Prize more

• 

  19.07.2023

  A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler

  CRC collaboration with Pfander lab published in Life Science Alliance more
• 

  11.07.2023

  Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling

  EMBO Reports article from the Torres-Padilla Lab more
• 

  22.06.2023

  IRTG 1064 Open Science Forum

  Open for all! Exchange experience and identify issues in the context of the SFB 1064 Open Science Program more
• 

  14.06.2023 – 16.06.2023

  Paris-Munich Epigenetics Workshop & Symposium

  An exciting exchange between the Paris and Munich epigenetic research communities more
• 

  28.04.2023

  The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus

  Life Science Alliance article from the Rupp lab more
• 

  27.04.2023

  Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1

  Nature Structural & Molecular Biology article from the Hopfner Lab more
• 

  18.04.2023

  Everything you always wanted to know about MS-based proteomics

  Seminar and question & answer session on Mass Spectrometry with experts from the ZFP Unit more
• 

  18.04.2023

  A change in biophysical properties accompanies heterochromatin formation in mouse embryos

  Genes & Dev article Guthmann et al. from the Torres-Padilla lab more
• 

  17.04.2023

  Heterochromatin definition and function

  Viewpoint article in Nature Reviews Molecular Cell Biology with CRC contributors Adam Burton and Maria Elena Torres Padilla more
• 

  05.04.2023

  Establishment and Function of Nucleosome Organization at Eukaryotic Chromosome Replication

  Nature article from the Kurat lab with CRC collaborators, and first author IRTG member Erika Chacin more
• 

  30.03.2023 – 31.03.2023

  interact 2023 – Science & Translation

  Register now to present your research, hear talks from big names in academia, industry and science communications! more
• 

  27.03.2023

  Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging

  Review in Developmental Cell from the Torres-Padilla lab more
• 

  21.02.2023

  ORE-Seq: Genome-Wide Absolute Occupancy Measurement by Restriction Enzyme Accessibilities

  Contribution in Methods in Molecular Biology volume from the Korber lab, first author Elisa Oberbeckmann more
• 

  20.02.2023

  Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components

  Nucleic Acids Research article – collaboration from the Leonhardt Lab more
• 

  31.01.2023

  Henriette Uhlenhaut receives ERC Consolidator Grant

  Funding and recognition for signature research project GRACE more
• 

  16.01.2023

  When should I eat: A circadian view on food intake and metabolic regulation

  Acta Physiologica review article with contribution from Henriette Uhlenhaut more
• 

  10.01.2023

  SPRTN patient variants cause global-genome DNA-protein crosslink repair defects

  Nature Communications article rom the Stingele Lab in collaboration with the Imhof Lab more
• 

  05.01.2023

  The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair

  Molecular Cell article from the Stingele lab more
• 

  27.12.2022

  Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation

  Cell Reports article from the Torres-Padilla lab more
• 

  20.12.2022

  CRC 1064 Seasons Greetings to All!

  From the Munich Chromatin Dynamics Community more
• 

  13.12.2022

  Swan Song Re-launch with Nik Eggers and Manuel Guthmann

  Final presentations from two of the IRTG's latest finishers more
• 

  08.12.2022

  Peter Becker new chair of EMBL Council

  The Council of the renowned European Molecular Biology Laboratory (EMBL) has named Peter Becker as the next chair of the governing body. more
• 

  24.11.2022

  Zygotic genome activation by the totipotency pioneer factor Nr5a2

  Science article from the lab of CRC Associate Kikuë Tachibana more
• 

  18.11.2022

  Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

  Nature Communications article from the Pfander lab more
• 

  15.11.2022

  Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance

  Cell Reports from the Schneider lab with collaboration from the Hamperl group more
• 

  15.11.2022

  High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression

  Nat Commun article with contribution from CRC Associate Rodrigo Villaseñor more
• 

  07.11.2022

  "More than just an emergency relief program"

  LMU News release about support for Ukranian researchers in the Munich scientific community more
• 

  27.10.2022

  Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger

  Nucleic Acids Reserach from the Leonhardt lab more
• 

  18.10.2022

  Altered expression response upon repeated gene repression in single yeast cells

  Collaboration between Schneider and Marr labs more
• 

  17.10.2022 – 20.10.2022

  EpIC - EpiGene3Sys meets INC_Spain to ChromDesign the Genome

  Registration will open soon! more
• 

  14.10.2022

  Film: Picture a Scientist

  Matinee viewing and informal discussion session at the BMC more
• 

  11.10.2022

  Trailblazer Lecture with Edith Heard, Director General EMBL Heidelberg

  EMBL's new science programme: "Molecules to Ecosystems" more
• 

  10.10.2022

  4th Munich Yeast Meeting

  at the Helmholtz Munich Campus Neuherberg, organized by Stephan Hamperl and Kurt Schmoller more
• 

  05.10.2022

  Biotech Career Opportunities in Munich

  Career orientation event at the BMC for early career scientists more
• 

  03.10.2022

  Integrative analysis of macrophage Ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes

  CSBJ article from the Uhlenhaut lab and colleagues more
• 

  29.09.2022

  Sustainable World 2022

  Global Challenges for Life Scientists more
• 

  19.09.2022

  The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery

  NSMB article from the Braun lab with first author IRTG-alumna Lucía Martín Caballero more
• 

  19.09.2022

  Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm

  Nature Communications article from the Schotta and Leonhardt labs, with first author IRTG-alum Zeyang Wang more
• 

  15.09.2022

  Probing cell identity hierarchies by fate titration and collision during direct reprogramming

  The latest from the Stricker lab and colleagues in Molecular Systems Biology more
• 

  08.09.2022

  Probing protein ubiquitination in live cells

  Nucleic Acids Research publication from the Leonhardt and Imhof labs more
• 

  28.08.2022 – 03.09.2022

  Four IRTG members selected for Spetses Summer School 2022

  Cancer Epigenetics - Principles, Applications and Single-Cell Resolution more
• 

  28.08.2022 – 03.09.2022

  Cancer Epigenetics - Principles, Applications and Single-Cell Resolution

  Spetses Summer School 2022 co-sponsored by the CRC 1064 more
• 

  25.08.2022

  LSGN PhD Student GET-TOGETHER

  Poster Session, Food, Drinks, Music more
• 

  13.08.2022

  XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

  Nature Communications article with first author Charlotte Blessing, IRTG graduate from the Ladurner Lab more
• 

  31.07.2022 – 03.08.2022

  IRTG 1064 retreat in San Servolo, Venice

  Creative scientific activities, inspiring views, a spectacular venue – and an amazing group of doctoral researchers! more
• 

  29.07.2022

  TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation

  SFB Collaboration with the Leonhardt, Bultmann, Schneider and Bartke labs more

• 23.07.2022

  IRTG member Vanessa Luzak contributes to Soapbox Science 2022

  Communicating to the public and promoting diversity in science more

• 

  21.07.2022

  Chromatin Day, July 21, 2022

  Hear about exciting chromatin research in Munich – this year for the first time in hybrid format! more
• 

  23.06.2022

  Identifying Specific Protein Interactors of Nucleosomes Carrying Methylated Histones Using Quantitative Mass Spectrometry

  Bartke lab contributes to "Methods in Molecular Biology" more
• 

  19.05.2022

  IRTG 1064 Open Science Forum

  Exchange experience and identify issues in the context of the SFB 1064 Open Science Program more
• 

  17.05.2022

  Epigenetik: Ewächst aus einem erweiterten Blick innerhalb der Genetik eine neue Verantwortung?

  Kurzvorträge von Philipp Korber und Christian Kummer mit offener Diskussion more
• 

  25.04.2022 – 29.07.2022

  Epigenetics: from molecules to ecosystems

  TUM Summer Semester Seminars 2022 more
• 

  05.04.2022

  Alumni Career Get-together

  Meet former IRTG members now in the workforce more
• 

  25.03.2022

  Histone post-translational modifications — cause and consequence of genome function

  Nat Rev Genet article by Robert Schneider (A20) and co-authors more
• 

  21.03.2022

  Solidarity for Scientists

  The SFB 1064 offers support for scientists of all levels displaced by the war in the Ukraine more
• 

  21.03.2022

  H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function

  NAR publication from the Smolle lab more
• 

  18.03.2022

  DNA–Protein Crosslinks and Their Resolution

  Pedro Weickert and Julian Stingele in the Annual Review of Biochemistry more
• 

  17.03.2022

  Yta7, a chromatin segregase regulated by the cell cycle machinery

  Molecular & Cellular Oncology article from the Kurat lab more
• 

  17.03.2022

  Nicolai Siegel awarded ERC Consolidator Grant

  Investigating the variability of pathogens more
• 

  07.03.2022

  DNA replication fork speed underlies cell fate changes and promotes reprogramming

  From the Torres Padilla lab in Nature Genetics more
• 

  17.02.2022

  Spatial organization of transcribed eukaryotic genes

  Nature Cell Biology article from the Solovei lab more
• 

  13.02.2022

  MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

  Nucleus article from a Leonhardt lab collaboration more
• 

  07.02.2022

  Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler

  Nature Neuroscience article from the Bonev Lab more
• 

  21.01.2022

  The fork protection complex recruits FACT to reorganize nucleosomes during replication

  Results of the Kurat Lab's collaboration with the Duderstadt lab and colleagues in Nucleic Acids Research more
• 

  12.01.2022

  DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling

  Review article in Frontiers in Genetics from the Pfander Lab more
• 

  23.12.2021

  Benchmarking atlas-level data integration in single-cell genomics

  Nature Methods publication with associate member Maria Colomé-Tatché more
• 

  23.12.2021

  Enhancer RNA Expression in Response to Glucocorticoid Treatment in Murine Macrophages

  Cells publication from the Uhlenhaut lab (A21) more
• 

  09.12.2021

  Chromatin "Morning" 2021 with Digitalks

  Join our virtual meeting to hear about exciting chromatin research in Munich more
• 

  06.12.2021

  IRTG member Hannah Reinking among the 2021 Römer Prize recipients

  Award for (post-)doctoral researchers for outstanding achievement in biochemistry and chemistry more
• 

  01.12.2021

  The biogenesis and function of nucleosome arrays

  Nature Communications article from the Müller-Planitz lab in collaboration with the Bioinformatics Core Facility more
• 

  28.10.2021

  Munich Epigenetics Spotlight 2021

  Register before Sept 30! Virtual meeting hosted by epigenetics@HMGU more
• 

  14.10.2021

  Morc3 silences endogenous retroviruses by enabling Daxx mediated histone H3.3 incorporation.

  Nature Communications article from the Schotta Lab (A11) more
• 

  08.10.2021

  Cell-to-Cell Heterogeneity in Trypanosomes

  First author Vanessa Luzak in Annual Review of Microbiology more
• 

  23.09.2021

  Molecular basis of human ATM kinase inhibition

  Nature Structural & Molecular Biology publication from the Hopfner lab more
• 

  22.09.2021

  3rd Munich Yeast Meeting 2021

  Organized by Stephan Hamperl (A29) and Kurt Schmoller of epigenetics@HMGU more
• 

  12.09.2021 – 26.09.2021

  1st LSGN MEME ART CONTEST

  And the winners are ... more
• 

  07.09.2021

  A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis

  New publication from the Rupp lab in cooperation with the Bioinformatics and Protein Analysis core facilities more
• 

  01.09.2021

  A CDK-regulated chromatin segregase promoting chromosome replication

  Nature Communications paper from the Kurat Lab, with collaborations from the Müller-Planitz and Pfander labs more
• 

  30.08.2021

  Julian Stingele receives Vallee Scholar Award

  Recognition as an outstanding early career scientist more
• 

  23.08.2021

  The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila

  PLOS Genetics article from the Imhof lab more
• 

  13.08.2021

  Nucleolar release of rDNA repeats for repair involves SUMO-mediated untehering by the Cdc48/p97 segregase

  Nature Communications article from the Braun, Ladurner and Pfander labs more
• 

  20.07.2021

  CRC Project Leaders Schneider and Torres Padilla elected to Academia Europeae

  Recognition for contributions in the field of cell and developmental biology more
• 

  28.06.2021

  Cell-free genomics reveal intrinsic, cooperative and competitive determinants of chromatin interactions

  Nik Eggers and Peter Becker publish in Nucleic Acids Research more
• 

  01.06.2021

  Profile features in LMU Einsichten – Das Forschungsmagazin

  Maria Robles and Julian Stingele are spotlighted for the LMU community more
• 

  01.06.2021

  Now Hiring: PhD positions

  Call for applications until June 30, 2021 more
• 

  21.05.2021

  Chromatin Dynamics will continue for 4 more years!

  DFG Senate approves funding for the third and final financial period 2021-2025 more
• 

  11.05.2021

  Bioimaging Day 2021

  A successful method spotlight with broad outreach! more
• 

  14.04.2021 – 15.04.2021

  Chromatin and Epigenetics: From Mechanisms to Execution

  Organized by Maria Elena Torres Padilla, Robert Schneider and Abcam more
• 

  25.03.2021 – 26.03.2021

  Reponsible Research 2021

  See the updated toolbox! more
• 

  04.03.2021

  HP1β carries an acidic linker domain and requires H3K9me3 for phase separation

  Publication Qin et al. from the Leonhardt lab more
• 

  01.03.2021

  Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes

  Online! from the Pfander Lab, Peritore et al. Mol Cell 2021 more
• 

  09.02.2021

  The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

  Cell Reports paper from the Uhlenhaut lab more
• 

  29.01.2021

  Succinylation of H3K122 destabilizes nucleosomes and enhances transcription

  From the Schneider lab in EMBO Reports more
• 

  25.01.2021

  A ubiquitin switch controls autocatalytic inactivationof the DNA–protein crosslink repair protease SPRTN

  Nucleic Acids Research paper from the Stingele lab more
• 

  20.01.2021

  Wie kommuniziert Wissenschaft?

  Diskussion mit Beispielen aus der aktuellen Coronavirus-Forschung an der LMU more
• 

  11.01.2021

  Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

  Nature Microbiology paper from the Siegel Lab more
• 

  01.12.2020

  CRC 1064 Associates named EMBO Young Investigators 2020

  Maria Robles and Julian Stingele among 30 new awardees more
• 

  24.11.2020

  Nature Communications paper from the Bultmann and Leonhardt labs

  Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals more

• 11.11.2020 – 13.11.2020

  The 6th German Xenopus Meeting

  Hosted this year by the Rupp Lab more

• 

  02.11.2020

  Munich Epigenetics Spotlight 2020

  Virtual meeting hosted by epigenetics@HMGU more
• 

  22.10.2020

  "Proteomics highlight of the year" awarded to Maria Robles

  First place in HUPO manuscript competition more
• 

  01.10.2020

  Chromatin Day, Oct 1, 2020

  Join our virtual meeting to hear about exciting chromatin research in Munich more
• 

  01.10.2020

  DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease

  Molecular Cell paper from the Stingele lab more
• 

  21.09.2020 – 14.09.2020

  Oktoberfest Lecture: Stirling Churchman

  Postponed to 2021 more
• 

  09.09.2020

  A protein assembly mediates Xist localization and gene silencing

  Nature article with contribution from the Leonhardt lab more
• 

  01.07.2020

  IRTG member Janet Tait gets up on her soapbox!

  Soapbox Science Munich – an initiative to increase visibility of current research by women in science more
• 

  29.06.2020

  Regulation of heterochromatin establishment during early mammalian development

  Nature Cell Biology publication from the Torres-Padilla Lab more
• 

  11.06.2020

  CRISPR-tools for physiology & cell state changes - potential of transcriptional engineering and epigenome editing

  From the Stricker lab in Physiological Reviews more
• 

  03.06.2020

  Maria Robles receives SRBR Junior Faculty Research Award

  2020 Award from Society for Research on Biological Rthythms more
• 

  01.04.2020

  Nuclear architecture in nocturnal animals – Review by Irina Solovei and colleagues

  Trends in Cell Biology (2020) 30 (4): 276-289 more
• 

  31.03.2020 – 02.04.2020

  IRTG members selected for EUGLOH Doctoral Camp on innovation and global health

  Sophia Groh, Lucía Martin Caballero and Daan Verhagen are among LMU awardees in new international program more
• 

  26.03.2020

  Ignatova et al. reports on the involvement of METTL5 in pluripotency and developmental programs

  Genes & Dev. paper from the Schneider Lab, incl. Bultmann lab collaboration more
• 

  20.03.2020

  Siegel lab: Epigenetics in Trypanosomes

  Nature Communications (2020) 11:1498 more
• 

  29.02.2020

  Sandro Baldi, Philipp Korber and Peter Becker: Review article on nucleosomal arrays and chromatin folding

  Nature Structural & Molecular Biology (2020) 27: 109-118 more
• 

  27.02.2020 – 28.02.2020

  interact 2020

  For junior researchers, by junior researchers more
• 

  28.01.2020

  Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Mathylation Landscapes

  Cell Reports paper from Imhof Lab more
• 

  16.01.2020

  Tunable light and drug induced depletion of target proteins

  Nature Communications article from the Leonhardt lab more
• 

  29.12.2019

  Oberbeckmann et al. (Korber lab) – Absolute nucleosome occupancy map for the yeast genome

  Genome Res. (2019) 12:1996-2009 more
• 

  17.12.2019

  Organtransplantation und Xenotransplantation

  Medizinische und Ethische Diskussion mit Publikumsbeteiligung more
• 

  11.12.2019

  Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

  eLife (2019) 8:e49542 collaboration with Irina Solovei more
• 

  15.11.2019

  Rodriguez-Terrones et al: A distinct metabolic state arises during the emergence of 2-cell-like cells

  EMBO reports (2019) e48354 from the Torres-Padilla lab more
• 

  16.10.2019

  Guthmann, Burton, Torres-Padilla: Expression and phase separation potential of heterochromatin proteins ...

  EMBO reports, 2019 more
• 

  11.10.2019

  Two 2019 Science papers from the lab of Maria Robles

  Science, vol. 366, issue 6462, 11 October 2019 more
• 

  10.10.2019 – 12.10.2019

  5th International Munich Chromatin Symposium 2019

  Many thanks to all participants for a successful and interesting meeting! more
• 

  23.09.2019 – 16.09.2019

  Oktoberfest Lecture 2019: Tony Kouzarides

  Monday, September 23 at 14:00 in the BMC Small Auditorium N02.040 more
• 

  27.07.2019

  Schotta lab reports on epigenetic regulation of pioneer transcription factor Foxa2

  Cernilogar et al., Nucleic Acids Research, 2019 more
• 

  25.07.2019

  Chromatin Day, July 25, 2019

  Save the date! Thursday, July 25, 2019 more
• 

  05.06.2019

  Associate Irina Solovei on compartmentalization of inverted and conventional nuclei

  Falk et al. (2019) Nature 570, 395-399 more
• 

  01.06.2019

  Dr. Susanne Bantele awarded Otto-Hahn Medal

  Pfander Lab member receives award for work on cell-cycle dependent regulation of DNA Repair more
• 

  30.05.2019

  Máté Borsos et al. from the Torres-Padilla lab reports on genome-lamina interactions in the early mouse embryo

  Nature 569, 729-733. more
• 

  16.05.2019

  A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling

  Harpprecht et al., Nucleic Acids Research, 2019 more
• 

  09.05.2019

  Targeted removal of epigenetic barriers during transcriptional reprogramming.

  Nature Communications publication from the Stricker Lab more
• 

  11.04.2019

  Sustainable World: Global Challenges for Life Scientists

  April 11, 2019. Thanks to all those who participated! more
• 

  01.04.2019

  Karl-Peter Hopfner receives ERC Advanced Grant

  One of three recipients at the LMU more
• 

  01.03.2019

  See the video: Life Scientists on Campus

  LMU researchers give testimonies to their research motivations and the benefits of working at the Life Science Campus more
• 

  21.11.2018

  Autumn Swan Song

  A year's end farewell to Ramona, Paulina, Alessandro and Lisa more
• 

  15.11.2018

  Baldi et al. – Genome-wide Rules of Nucleosome Phasing in Drosophila

  Molecular Cell 72, 661-672, 2018 more
• 

  15.11.2018

  Bartke and Bultmann characterize the E3 ubiquitin ligase mechanism of UHRF1 and its role in DNA methylation

  Molecular Cell 72, 739-752, 2018 more
• 

  09.11.2018

  Regulation of Transcription: RNA Pol II and Myc

  In honor of Dirk Eick's 65th more
• 

  27.09.2018

  Sequencing Spotlight in September

  Learn about cutting-edge seq techniques from the experts in the local scientific community in an informal half-day symposium more
• 

  24.09.2018

  Oktoberfest Lecture 2018: Dirk Schübeler

  Monday, September 24 at 11:00 in the BMC Small Auditorium N02.040 more
• 

  21.09.2018

  Cell-to-Cell Heterogeneity in Chromatin Structure

  Mini-symposium on September 21, 2018 in the BMC more
• 

  12.09.2018 – 13.09.2018

  The Secrets of Chromatin, September 12-13, 2018

  Sexaginta! more
• 

  20.07.2018

  Chromatin Day, July 20, 2018

  Save the date! Friday, July 20, 2018 more
• 

  05.06.2018

  MIT:FUTURA 2018 prize goes to Moritz Völker-Albert and the EpiQMax Team

  Congratulations for the outstanding recognition of the start-up initiative EpiQMAx! more
• 

  18.04.2018 – 06.06.2018

  It's Swan Song Season! April 18, May 9 and June 6

  Moritz & Gustavo, Nina & Stefanie and Andrea S. & Alessio will be giving their final presentations. All are welcome! more
• 

  01.04.2018

  Müller lab: Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC

  Schmähling et al., Development 145(7), 2018 more
• 

  08.03.2018

  Entering the post-epigenomic age: back to epigenetics.

  Joint publication with Sebastian Bultmann and Stefan Stricker more
• 

  22.02.2018

  Developmental Programming and Reprogramming

  ITN workshop on February 22, 2018 in the BMC more
• 

  01.02.2018

  DNA-methylation: master or slave of neural fate decisions?

  Frontiers of Neuroscience Review authored by Stefan Stricker and Magdalena Götz more
• 

  07.01.2018

  Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection

  Boris Pfander's lab publishes in eLife more
• 

  01.01.2018

  Alessandro Angerilli (AG Rupp) – The Xenopus animal cap transcriptome: Building a mucociliary epithelium

  Nucleic Acids Res. (2018) 46 (17): 8772-8787 more
• 

  07.12.2017

  Hari R. Singh (Ladurner lab) et al: A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

  Molecular Cell 68, 860-871, 2017 more
• 

  28.11.2017

  DAAD Award 2017 to IRTG member

  Congratulations to Ashish Singh, PhD researcher in the Müller-Planitz lab more
• 

  21.11.2017 – 22.11.2017

  SFB 1064 contributes: From Chromatin to RNA - A Systems View on Molecular Mechanisms

  EMBL-DFG Women in Science Network Conference more
• 

  18.09.2017

  Oktoberfest Lecture 2017: Karolin Luger

  Monday, September 18 at 17:00 in the Small Auditorium N02.040 more
• 

  18.09.2017

  See the film! Responsible Research July 20, 2017

  A campus-wide event for next-generation researchers more
• 

  27.07.2017

  Chromatin Day, July 27, 2017

  Save the date! Thursday, July 27, 2017 more
• 

  24.05.2017

  CRC 1064 funding renewal 2017-2021

  DFG Senate elects to extend funding for the next four years. more
• 

  24.03.2017

  Solovei & Joffe: Small chromosomal regions position themselves autonomously according to their chromatin class

  van de Werken et al., Genome Research 27:922-933, 2017 more
• 

  15.03.2017

  Jürg Müller on the genetic transmission of gene locks

  Science 356 (6333) 85-88, 2017 more
• 

  24.02.2017

  IRTG-SFB 1064 member receives the DAAD Award

  Daniil Pokrovsky, doctoral candidate in the lab of Ralph Rupp, is the LMU Munich award-winner more
• 

  30.11.2016

  New building blocks: nucleosomes as part of DNA origamis

  More news from the Korber group more
• 

  29.11.2016

  Genomic nucleosome organization reconstituted with pure proteins

  News from the Korber group more
• 

  10.03.2016 – 12.03.2016

  In retrospect: Chromatin Dynamics Symposium