Seminars, Events & Resources

All SFB Seminars are scheduled here – please have a look for the upcoming events.
Seminars are regularly scheduled on Thursdays at 11:00 more

See the detailed animations from the Nature Reviews Molecular Biology article "Energy-driven genome regulation by ATP-dependent chromatin remodellers" co-authored by SFB members Philipp Korber and Karl-Peter Hopfner (Eustermann et al. 2023) more

• Animation 1: Nucleosome organization by ATP-dependent chromatin remodellers at gene promoters
• Animation 2: Architecture and mechanisms of the SWI/SNF-family remodeller RSC
• Animation 3: Architecture and mechanisms of the INO80-family remodeller INO80
• Animation 4: Architecture and mechanism of the CHD-family remodeller Chd1

October 9-11, 2024 more

Our annual meeting to learn about exciting chromatin research in Munich!

Watch for our farewell CHROMATIN DAYS on May 26-27, 2025! more

An exciting exchange between the Paris and Munich epigenetic research communities. more

• Paris-Munich Epigenetics Gallery
• Symposium Programme – Paris-Munich Epigenetics, June 14-16, 2023
• Workshop Programme – Paris-Munich Epigenetics 2023

Researchers give testimonies about their research motivations and the scientific community at the LMU Life Science Campus in Großhadern/Martinsried.
See CRC 1064 project leaders Henriette Uhlenhaut, Felix Müller-Planitz and Sigurd Braun as well as associates Stefan Stricker, Julian Stingele and Nicolai Siegel. more

The meeting offered outstanding speakers and poster presentations for exchange and discussion on the dynamic organisation of chromatin structure and their function to support nuclear processes.

October 10-12, 2019, Biomedical Center Munich, Small Lecture Hall N02.040
Many thanks to all participants for their contributions in making this a successful and interesting meeting! more

November 9, 2018
In honor of Dirk Eick: A career dedicated to understanding gene expression more

• Pol II Symposium Photo Gallery

September 12-13, 2018 at the BMC more

February 22, 2018 more

• Developmental Programming 2018 Photo Impressions
• Final program: Developmental Programming and Reprogramming

The 4th Munich Chromatin Symposium on Chromatin Dynamics took place from March 10-12, 2016. more

• Developmental Programming and Reprogramming
• Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation
• CRC Project Leaders Schneider and Torres Padilla elected to Academia Europeae
• Optimizing biomedical information retrieval with a keyword frequency-driven Prompt Enhancement Strategy
• Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis
• Alessandro Angerilli (AG Rupp) – The Xenopus animal cap transcriptome: Building a mucociliary epithelium
• The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus
• Integrative analysis of macrophage Ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes
• Autumn Swan Song
• Baldi et al. – Genome-wide Rules of Nucleosome Phasing in Drosophila
• Sandro Baldi, Philipp Korber and Peter Becker: Review article on nucleosomal arrays and chromatin folding
• Yta7, a chromatin segregase regulated by the cell cycle machinery
• Dr. Susanne Bantele awarded Otto-Hahn Medal
• Decoding the impact of nuclear organization on antigenic variation in parasites
• Bartke and Bultmann characterize the E3 ubiquitin ligase mechanism of UHRF1 and its role in DNA methylation
• Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
• Peter Becker new chair of EMBL Council
• Heterochromatin definition and function
• Trailblazer Lecture with Shelley Berger (University of Pennsylvania)
• Bioimaging Day 2021
• Bioinformatics Day 2024
• Biotech Career Opportunities in Munich
• Biotech & Pharma Career Day 2024
• XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
• A single fiber view of the nucleosome organization in eukaryotic chromatin
• Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler
• Máté Borsos et al. from the Torres-Padilla lab reports on genome-lamina interactions in the early mouse embryo
• CRISPR-tools for physiology & cell state changes - potential of transcriptional engineering and epigenome editing
• Entering the post-epigenomic age: back to epigenetics.
• Regulation of heterochromatin establishment during early mammalian development
• The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
• Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling
• Nucleolar release of rDNA repeats for repair involves SUMO-mediated untehering by the Cdc48/p97 segregase
• Alumni Career Get-together
• Alumni Career Get-together
• Biotech & Pharma Career Day 2023
• Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
• Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS
• Cell-to-Cell Heterogeneity in Chromatin Structure
• Schotta lab reports on epigenetic regulation of pioneer transcription factor Foxa2
• A CDK-regulated chromatin segregase promoting chromosome replication
• Establishment and Function of Nucleosome Organization at Eukaryotic Chromosome Replication
• When should I eat: A circadian view on food intake and metabolic regulation
• Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency
• Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells
• The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry
• Chromatin Day, July 27, 2017
• Chromatin Day, July 20, 2018
• Chromatin Day, July 25, 2019
• Chromatin Day, Oct 1, 2020
• Chromatin "Morning" 2021 with Digitalks
• Chromatin Day, July 21, 2022
• Chromatin Day, July 27, 2023
• Chromatin Day, July 22, 2024
• Chromatin Days: Reunion & Valediction – May 26-27, 2025
• In retrospect: Chromatin Dynamics Symposium
• Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1
• Benchmarking atlas-level data integration in single-cell genomics
• Cellular responses to RNA damage
• Chromatin Dynamics will continue for 4 more years!
• Maria Robles is awarded research grant from the Chan Zuckerberg Inititiative
• DAAD Award 2017 to IRTG member
• IRTG-SFB 1064 member receives the DAAD Award
• CRC 1064 International Symposium POSTER DESIGN COMPETITION
• Stem Cells & Ethics
• Diversity, Identity & Fate at Biomedical Frontiers
• A non-proteolytic release mechanism for HMCES-DNA-protein crosslinks
• Cell-free genomics reveal intrinsic, cooperative and competitive determinants of chromatin interactions
• Profile features in LMU Einsichten – Das Forschungsmagazin
• CRC 1064 Associates named EMBO Young Investigators 2020
• EpIC - EpiGene3Sys meets INC_Spain to ChromDesign the Genome
• Chromatin and Epigenetics: From Mechanisms to Execution
• Munich Epigenetics Spotlight Meeting
• Epigenetik: Ewächst aus einem erweiterten Blick innerhalb der Genetik eine neue Verantwortung?
• Munich Epigenetics Spotlight 2020
• Munich Epigenetics Spotlight 2021
• Munich Epigenetics Spotlight 2024
• Maria Elena Torres-Padilla is awarded Leibniz Prize 2024
• Energy-driven genome regulation by ATP-dependent chromatin remodellers
• Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes
• Cell-to-Cell Heterogeneity in Trypanosomes
• Nuclear architecture in nocturnal animals – Review by Irina Solovei and colleagues
• Charlotte Blessing receives dissertation prize
• Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection
• Zygotic genome activation by the totipotency pioneer factor Nr5a2
• Morc3 silences endogenous retroviruses by enabling Daxx mediated histone H3.3 incorporation.
• IRTG members selected for EUGLOH Doctoral Camp on innovation and global health
• Guthmann, Burton, Torres-Padilla: Expression and phase separation potential of heterochromatin proteins ...
• A change in biophysical properties accompanies heterochromatin formation in mouse embryos
• A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling
• Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger
• Trailblazer Lecture with Edith Heard, Director General EMBL Heidelberg
• Disordered protein regions partner up the cBAF remodeler for a chromatin dance
• Probing cell identity hierarchies by fate titration and collision during direct reprogramming
• Now Hiring: PhD positions
• CRC 1064 Seasons Greetings to All!
• Karl-Peter Hopfner receives ERC Advanced Grant
• FrozONE: quick cell nucleus enrichment for comprehensive proteomics analysis of frozen tissues
• Ignatova et al. reports on the involvement of METTL5 in pluripotency and developmental programs
• Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Mathylation Landscapes
• MIT:FUTURA 2018 prize goes to Moritz Völker-Albert and the EpiQMax Team
• interact 2020
• interact 2023 – Science & Translation
• interact 2025 – Our Collective Impact
• IRTG 1064 Retreat, August 7-9, 2023 at the Söllerhaus
• ‘Digital Reprogramming’ Decodes Epigenetic Barriers of Cell Fate Changes
• Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers
• DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling
• A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler
• Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers
• Genomic determinants of antigen expression hierarchy in African trypanosomes
• DNA mimic foldamers affect chromatin composition and disturb cell cycle progression
• Genomic nucleosome organization reconstituted with pure proteins
• New building blocks: nucleosomes as part of DNA origamis
• Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance
• The origin of septin ring size control in budding yeast
• Hari R. Singh (Ladurner lab) et al: A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene
• Spatial organization of transcribed eukaryotic genes
• Nature Communications paper from the Bultmann and Leonhardt labs
• Tunable light and drug induced depletion of target proteins
• H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function
• See the video: Life Scientists on Campus
• LSGN PhD Student GET-TOGETHER
• The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila
• Decoding chromatin states by proteomic profiling of nucleosome readers
• SLAM-seq reveals independent contributions of RNA processing and stability to gene expression in African trypanosomes.
• IRTG member Vanessa Luzak contributes to Soapbox Science 2022
• The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
• Context-dependent epigenome rewiring during neuronal differentiation
• High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes
• 1st LSGN MEME ART CONTEST
• Histone post-translational modifications — cause and consequence of genome function
• "More than just an emergency relief program"
• Jürg Müller on the genetic transmission of gene locks
• A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation
• 3rd Munich Yeast Meeting 2021
• 4th Munich Yeast Meeting
• Pioneers conquer core histones at the chromatin frontier
• DNA replication fork speed underlies cell fate changes and promotes reprogramming
• A protein assembly mediates Xist localization and gene silencing
• G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism
• H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
• Oberbeckmann et al. (Korber lab) – Absolute nucleosome occupancy map for the yeast genome
• ORE-Seq: Genome-Wide Absolute Occupancy Measurement by Restriction Enzyme Accessibilities
• Oktoberfest Lecture 2017: Karolin Luger
• Oktoberfest Lecture 2018: Dirk Schübeler
• Oktoberfest Lecture 2019: Tony Kouzarides
• Oktoberfest Lecture: Stirling Churchman
• An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
• Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo
• IRTG 1064 Open Science Forum
• IRTG 1064 Open Science Forum
• IRTG 1064 Open Science Forum
• Organtransplantation und Xenotransplantation
• Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity
• PLK1-Mediated Phosphorylation Cascade Activates Mis18 Complex to Ensure Centromere Inheritance
• Paris-Munich Epigenetics Workshop & Symposium 2025
• Paris-Munich Epigenetics Workshop & Symposium
• Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins
• Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1
• Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes
• Nitin Phadnis: Genomic Conflicts and the Origins of Species
• Film: Picture a Scientist
• A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis
• Regulation of Transcription: RNA Pol II and Myc
• Everything you always wanted to know about MS-based proteomics
• The influencers' era: how the environment shapes chromatin in 3D
• HP1β carries an acidic linker domain and requires H3K9me3 for phase separation
• Probing protein ubiquitination in live cells
• Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes
• epiAneufinder identifies copy number alterations from single-cell ATAC-seq data
• CRC 1064 funding renewal 2017-2021
• DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
• IRTG member Hannah Reinking among the 2021 Römer Prize recipients
• See the film! Responsible Research July 20, 2017
• Reponsible Research 2021
• Responsible Research 2024
• IRTG Retreat 2024
• IRTG 1064 retreat in San Servolo, Venice
• Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions
• "Proteomics highlight of the year" awarded to Maria Robles
• Two 2019 Science papers from the lab of Maria Robles
• Maria Robles receives SRBR Junior Faculty Research Award
• Rodriguez-Terrones et al: A distinct metabolic state arises during the emergence of 2-cell-like cells
• The fork protection complex recruits FACT to reorganize nucleosomes during replication
• Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS
• Müller lab: Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC
• Smoother: on-the-fly processing of interactome data using prefix sums
• Altered expression response upon repeated gene repression in single yeast cells
• Sciencerely, a science communication YouTube channel, receives Silver Creator Award
• IRTG member Jie Hua (AG Imhof) slams for science!
• The Secrets of Chromatin, September 12-13, 2018
• Sequencing Spotlight in September
• Succinylation of H3K122 destabilizes nucleosomes and enhances transcription
• Nicolai Siegel awarded ERC Consolidator Grant
• Siegel lab: Epigenetics in Trypanosomes
• Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing
• The biogenesis and function of nucleosome arrays
• Sleep research award goes to Maria Robles
• Soapbox Science Munich 2024
• IRTG member Janet Tait gets up on her soapbox!
• Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
• Solovei & Joffe: Small chromosomal regions position themselves autonomously according to their chromatin class
• Associate Irina Solovei on compartmentalization of inverted and conventional nuclei
• Cancer Epigenetics - Principles, Applications and Single-Cell Resolution
• Four IRTG members selected for Spetses Summer School 2022
• asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers
• Molecular basis of human ATM kinase inhibition
• Generation of densely labeled oligonucleotides for the detection of small genomic elements
• Generation of densely labeled oligonucleotides for the detection of small genomic elements
• STEM PASSION: A journey inspired by women in science
• Julian Stingele receives Vallee Scholar Award
• TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
• Targeted removal of epigenetic barriers during transcriptional reprogramming.
• DNA-methylation: master or slave of neural fate decisions?
• Reprogramming Stars #15: Colliding Cellular Reprogramming Paths, an Interview with Prof. Dr. Stefan Stricker
• Sustainable World: Global Challenges for Life Scientists
• Sustainable World 2022
• Swan Song Re-launch with Nik Eggers and Manuel Guthmann
• It's Swan Song Season! April 18, May 9 and June 6
• 5th International Munich Chromatin Symposium 2019
• 6th Munich International Chromatin Symposium – Chromatin Dynamics
• Structural basis for Mis18 complex assembly and its implications for centromere maintenance
• Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging
• Epigenetics: from molecules to ecosystems
• Identifying Specific Protein Interactors of Nucleosomes Carrying Methylated Histones Using Quantitative Mass Spectrometry
• Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States
• Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components
• Henriette Uhlenhaut receives ERC Consolidator Grant
• Enhancer RNA Expression in Response to Glucocorticoid Treatment in Murine Macrophages
• The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
• Solidarity for Scientists
• The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
• Co-transcriptional splicing is delayed in the highly expressed thyroglobulin gene
• 3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
• High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression
• The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity
• Rodrigo Villaseñor is awarded ERC Starting Grant
• ISWI catalyzes nucleosome sliding in condensed nucleosome arrays
• Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm
• Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).
• SPRTN patient variants cause global-genome DNA-protein crosslink repair defects
• Electro-elution-based purification of covalent DNA–protein cross-links
• DNA–Protein Crosslinks and Their Resolution
• Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
• Wie kommuniziert Wissenschaft?
• Engineering an inducible leukemia-associated transcription factor enables large-scale ex vivo production of functional human phagocytes
• Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1
• SFB 1064 contributes: From Chromatin to RNA - A Systems View on Molecular Mechanisms
• The 6th German Xenopus Meeting
• The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair
• MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation
• A ubiquitin switch controls autocatalytic inactivationof the DNA–protein crosslink repair protease SPRTN
• RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
• Trailblazer Lecture with Xiaowei Zhuang
• Memory of Somatic Cell Identity Affects Specific Cell Differentiation Programs Upon Reprogramming In Vivo
• Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory