The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
Ullrich S, Leidescher S, Feodorova Y, Thanisch K, Fini JB, Kaspers B, Weber F, Markova B, Fuehrer D, Romitti M, Krebs S, Blum H, Leonhardt H, Costagliola S, Heuer H and Solovei I (2023) The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes. Front. Cell Dev. Biol., 11, 1265407. DOI 10.3389/fcell.2023.1265407
Abstract cited directly from the article:
Abnormalities are indispensable for studying normal biological processes and mechanisms. In the present work, we draw attention to the remarkable of a perpetually and robustly upregulated gene, the gene (Tg). The gene is expressed in the thyroid gland and, as it
has been recently demonstrated, forms so-called transcription loops, easily by light microscopy. Using this feature, we show that Tg is
expressed at a high level from the moment a thyroid cell acquires its identity both alleles remain highly active over the entire life of the cell, i.e., for months years depending on the species. We demonstrate that this high upregulation is of thyroglobulin genes in all major vertebrate groups. We provide evidence that Tg is not influenced by the thyroid hormone status, does not round the clock and is expressed during both the exocrine and phases of thyrocyte activity. We conclude that the thyroglobulin represents a unique and valuable model to study the maintenance of a transcriptional upregulation.