SFB 1064

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A02 - Chromatin regulation at promoters and enhancers, a molecular-mechanistic analysis

Our goal is to understand the regulation of gene expression in Drosophila development, and in particu-lar the interplay between transcription factor activity and chromatin organization. Building on a com-prehensive genome-wide analysis of core promoters, we plan to use sensitive proteomics approaches to characterize the interactome of selected general transcription machinery components and histone modifications in a promoter-type specific fashion. In a second aim, we seek to characterize the role of pioneer transcription factors in regulating chromatin accessibility at enhancers within the Ecdysone signaling cascade.

Gaul, Ulrike

Prof. Dr. Ulrike Gaul

BioSysM, Gene Center, LMU Munich