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Ladurner, Andreas

Prof. Andreas Ladurner, Ph.D.

Biomedical Center Munich - Physiological Chemistry,
LMU Munich

Responsibilities

Equal Opportunity Officer
Project A03: A poly-ADP-ribose switch releases the autoinhibition of the oncogenic remodeler Alc1/Chd1L

Contact

Biomedical Center Munich, LMU Munich
Department of Physiological Chemistry
Grosshaderner Str. 9
82152 Planegg-Martinsried
Germany

Room: B2.022
Phone: +49 (0)89 2180 - 77095
Fax: +49 (0)89 2180 - 77093

Website: Molecular Mechanisms of Chromatin Plasticity

Work group

Project A03

Curriculum Vitae

Academic Education

  • 1990 - 1994 B.Sc. (Honours) Biochemistry; University of York, UK Mentors: Dr. Anthony J. Wilkinson, Prof. Guy Dodson
  • 1994 Herchel Smith Foundation, Cambridge University, Predoctoral Stipend
  • 1994 Medical Research Council, Predoctoral Stipend 1995 Boehringer Ingelheim Fonds (BIF), Predoctoral Stipend

Advanced Professional Degrees

  • 2000 PhD, MRC Centre for Protein Engineering; University of Cambridge, UK Mentor: Prof. Sir Alan R. Fersht

Positions held

  • since 10/2010 Full Professor and Head of Physiological Chemistry, Adolf-Butenandt- Institute, Faculty of Medicine, Ludwig-Maximilians-Universität, München
  • 2003 - 2011 Group leader, Genome Biology Unit and Structural & Computational Unit, European Molecular Biology Laboratory (EMBL), Heidelberg
  • 2002 - 2003 Editor, Nature Structural & Molecular Biology, New York, USA
  • 1998 - 2002 Postdoctoral fellow with Prof. R. Tjian, Howard Hughes Medical Institute, University of California, Berkeley, USA
  • 1992 - 1993 Research Scientist, SmithKline Beecham Pharmaceuticals, Great Burgh, UK

Honours and Awards

  • since 2016 Elected Member of the Study section „Cell Biology‟ Deutsche Forschungsgemeinschaft (DFG Fachgutachter Zellbiologie)
  • 2015 Wilhelm-Vaillant-Prize
  • 2012 Elected member European Molecular Biology Organization (EMBO), Heidelberg
  • 2012 Member, DFG Excellence Cluster “Center for Integrated Protein Science Munich” (CIPSM)
  • 2012 Member, DFG Excellence Cluster “Munich Cluster for Systems Neurology” (SyNergy)
  • 2012  Member, Bavarian Research Network for Molecular Biosystems (BioSysNet)
  • 2011 Member, International Max-Planck-Research School (IMPRS), Munich
  • 2011 Member of the Scientific Advisory Board of Volition Inc., Singapore
  • 2010 Member of the Rector’s Advisory Board, Universita’ di Milano, Italy
  • 2009 Young Investigator Award, Schering Foundation
  • 2006 - 2009 Young Investigator Award, Human Frontier Science Programme
  • 2008 Outstanding Young Investigator Award, International Association for Protein Structure Analysis & Proteomics
  • 1998 - 2002 Wellcome Trust, International Prize
  • 1995 Boehringer Ingelheim Fonds (BIF), Predoctoral Stipend
  • 1994 Herchel Smith Foundation, Cambridge University, Predoc Stipend
  • 1994 Medical Research Council, Predoctoral Stipend

Editorial activities

  • 2002 - 2003 Editor, Nature Structural & Molecular Biology, New York, USA Other professional activities
  • 2009 – 2013 Coordinator, EU FP7 Marie Curie Network Nucleosome4D (22 labs)
  • 2006 – 2010 Coordinator, FP6 Marie Curie Network Chromatin Plasticity (13 labs)
  • 2006 – 2010 Coordinator, Human Frontier Science Programme, Programme Grant

Other professional activities

  • 2016-2020 Coordinator, EU Horizon2020 Marie Curie Network „ChroMe‟
  • since 2014 Board Member, DFG Collaborative Research Center 646
  • since 2013 Board Member, DFG Collaborative Research Center 1064
  • 2013-2017 Coordinator, BMBF NEURON-Network Project „Food4Thought‟
  • since 2012 Board Member, DFG Excellence Cluster CiPSM
  • since 2012 Member, DFG Excellence Cluster Synergy
  • since 2012 Member, Bavarian Research Network for Molecular Biosystems
  • since 2011 Member of the International Max Planck Research School (IMPRS)
  • 2010-2016 Training Coordinator, EU FP7 Network of Excellence „EpiGeneSys‟
  • 2009-2015 Member of the Advisory Board to the Rector, University of Milan, Italy
  • 2009-2013 Coordinator, EU FP7 Marie Curie Network „Nucleosome4D‟
  • 2006-2010 Coordinator, EU FP6 Marie Curie Network „Chromatin Plasticity‟

Selected CRC project-related publications

Bowman, A., Koide, A., Goodman, J.S., Colling, M.E., Zinne, D., Koide, S., and Ladurner, A.G. (2016). sNASP and ASF1A function through both competitive and compatible modes of histone binding. Nucleic Acids Research, doi: 10.1093/nar/gkw892.

Kistemaker, H.A.V., Nardozza, A.P., Overkleeft, H.S., van der Marel, G.A., Ladurner, A.G.*, and Filippov, D.V.* (2016). Synthesis and macrodomain binding of mono-ADP-ribosylated peptides. Angewandte Chemie 55, 10634–10638.

Peleg, S., Feller, C., Forne, I., Schiller, E., Sévin, D.C., Schauer, T., Regnard, C., Straub, T., Prestel, M., Klima, C., Schmitt, Nogueira M., Becker, L., Klopstock, T., Sauer, U., Becker, PB, Imhof, A.*, and Ladurner, A.G.* (2016). Lifespan extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep 17, 455–469.

Bowman, A., Lercher, L., Singh, H.R., Zinne, D., Timinszky, G., Carlomagno, T., and Ladurner, A.G. (2016). The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats. Nucleic Acids Research 44, 3105–3117.

Czarna, A., Berndt, A., Singh, H.R., Grudziecki, A., Ladurner, A.G., Timinszky, G., Kramer, A., and Wolf, E. (2013). Structures of Drosophila Cryptochrome and mouse Cryptochrome1 provide insight into circadian function. Cell 153, 1394–1405.