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Schotta, Gunnar

Prof. Dr. Gunnar Schotta

Biomedical Center - Molecular Biology, LMU Munich

Responsibilities

Project A11: Characterization of Morc3, a novel factor in retrotransposon silencing

Contact

Biomedical Center
Molecular Biology
Großhaderner Str. 9
82152 Plangegg-Martinsried
Germany

Phone: +49 (0)89 2180 - 75422

Website: Epigenetic Gene Regulation

Work group

Project A11

Curriculum Vitae

Academic Education

  • 1997 Diploma thesis in biochemistry, Advisor: Dr. Rainer Dorn, Martin-Luther University Halle
  • 1991-1997 Study of Biochemistry, Martin-Luther University Hallefinal grade “very good”

Advanced Professional Degrees

  • 2002 Ph.D. "summa cum laude"
  • 1997-2002 Ph.D. Thesis "Structure-function analysis of SU(VAR)3-9, an integral component of heterochromatic complexes." Advisor: Prof. G. Reuter, Martin-Luther-Universität, Halle

Positions held

  • since 2008 W2-Professor for Epigenetics, Adolf-Butenandt-Institute, Faculty of Medicine, Ludwig-Maximilians-Universität München
  • since 2008 Member of the ‘Center for Integrated Protein Science Munich’
  • 2003-2008 Postdoctoral fellow with Prof. T. Jenuwein, Institute of Molecular Pathology (I.M.P.), Vienna. Marie Curie Intra European Fellowship  (2004-2006)
  • 2002-2003 Postdoctoral fellow with Prof. G. Reuter, Martin-Luther-Universität,Halle

Others

  • Reviewer for ERC (advanced grants), DFG, ETH Zurich, Dutch Cancer Foundation, several high-profile peer-reviewed journals

Selected CRC project-related publications

Pasquarella, A., Ebert, A., Pereira de Almeida, G., Hinterberger, M., Kazerani, M., Nuber, A., Ellwart, J., Klein, L., Busslinger, M., and Schotta, G. (2016). Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells. Development 143, 1788-1799.

Ramesh, V., Bayam, E., Cernilogar, F.M., Bonapace, I.M., Schulze, M., Riemenschneider, M.J., Schotta, G., and Götz, M. (2016). Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration. Genes Dev 30, 2199-2212.

Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F.J., and Schotta, G. (2015). Atrx promotes heterochromatin formation at retrotransposons. EMBO Rep 16, 836-850.

Bierhoff, H., Dammert, M.A., Brocks, D., Dambacher, S., Schotta, G., and Grummt, I. (2014). Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing. Mol Cell 54, 675-682.

Hahn, M., Dambacher, S., Dulev, S., Kuznetsova, A.Y., Eck, S., Worz, S., Sadic, D., Schulte, M., Mallm, J.P., Maiser, A., Debs, P., von Melchner, H., Leonhardt, H., Schermelleh, L., Rohr, K., Rippe, K., Storchova, Z., and Schotta, G. (2013). Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin. Genes Dev 27, 859-872.