Responsibilities
Project A34 - Detection and repair of covalent DNA-histone crosslinks
Contact
LMU Munich
Feodor-Lynen-Str. 25
81377 Munich
Germany
Phone:
+49 89 2180 71080
Email:
stingele@genzentrum.lmu.de
Website:
Stingele Lab – Cellular Biochemistry
Curriculum Vitae
Academic Education
2010 Diploma in Biology, University of Konstanz, Germany
Advanced Professional Degrees
2015 PhD in Biology, LMU Munich with Professor Stefan Jentsch, Max Planck Institute of Biochemistry, Martinsried, Germany, summa cum laude
Positions held
- since Oct 2017 Tenure-track Professor of Cellular Biochemistry (W2), Gene Center and Department of Biochemistry, LMU Munich
- 2014- 2017 Postdoctoral Research Fellow with Professor Simon Boulton at The Francis Crick Institute, London, UK
Awards and Fellowships
- 2020 EMBO Young Investigator Programme
- 2019 Bayer Early Excellence in Science Award
- 2018 ERC Starting Grant: DNAProteinCrosslinks
- 2018 Alfried Krupp-Förderpreis für junge Hochschullehrer
- 2015 EMBO Long-Term Fellowship
- 2014 Max Planck Institute of Biochemistry Junior Research Award
Selected CRC-related publications:
Zhao S, Kieser A, Li HY, Reinking HK, Weickert P, Euteneuer S, Yaneva D, Acampora AC, Goetz MJ, Feederle R, Stingele J (2021) A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. Nucleic Acids Res., 49(2):902-915
Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Stingele J (2020) DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease. Mol Cell 80: 102-113.e106
Reinking HK, Hofmann K, Stingele J (2020) Function and evolution of the DNA-protein crosslink proteases Wss1 and SPRTN. DNA Repair 88: 102822-102822
Stingele J, Bellelli R, Boulton SJ (2017) Mechanisms of DNA-protein crosslink repair. Nat Rev Mol Cell Biol 18: 563-573
Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjaer S, Tainer JA, Skehel JM, Groll M, Boulton SJ (2016) Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Mol Cell 64: 688-703
Stingele J, Schwarz MS, Bloemeke N, Wolf PG, Jentsch S (2014) A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair. Cell 158: 327-338