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Stingele, Julian

Prof. Dr. Julian Stingele

Department of Cellular Biochemistry, LMU Gene Center

Responsibilities

Project A34 - Detection and repair of covalent DNA-histone crosslinks

Associated member since 2018
Project leader since 2021

Contact

Gene Center and Department of Biochemistry
LMU Munich
Feodor-Lynen-Str. 25
81377 Munich
Germany

Phone: +49 89 2180 71080

Website: Stingele Lab – Cellular Biochemistry

Work group

Project A34

Curriculum Vitae

Academic Education

2010  Diploma in Biology, University of Konstanz, Germany

Advanced Professional Degrees

2015  PhD in Biology, LMU Munich with Professor Stefan Jentsch, Max Planck Institute of Biochemistry, Martinsried, Germany, summa cum laude

Positions held

  • since Oct 2017  Tenure-track Professor of Cellular Biochemistry (W2), Gene Center and Department of Biochemistry, LMU Munich
  • 2014- 2017  Postdoctoral Research Fellow with Professor Simon Boulton at The Francis Crick Institute, London, UK

Awards and Fellowships

  • 2020 EMBO Young Investigator Programme
  • 2019 Bayer Early Excellence in Science Award
  • 2018 ERC Starting Grant: DNAProteinCrosslinks
  • 2018 Alfried Krupp-Förderpreis für junge Hochschullehrer
  • 2015 EMBO Long-Term Fellowship
  • 2014 Max Planck Institute of Biochemistry Junior Research Award

Selected CRC-related publications:

Zhao S, Kieser A, Li HY, Reinking HK, Weickert P, Euteneuer S, Yaneva D, Acampora AC, Goetz MJ, Feederle R, Stingele J (2021) A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. Nucleic Acids Res., 49(2):902-915

Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Stingele J (2020) DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease. Mol Cell 80: 102-113.e106

Reinking HK, Hofmann K, Stingele J (2020) Function and evolution of the DNA-protein crosslink proteases Wss1 and SPRTN. DNA Repair 88: 102822-102822

Stingele J, Bellelli R, Boulton SJ (2017) Mechanisms of DNA-protein crosslink repair. Nat Rev Mol Cell Biol 18: 563-573

Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjaer S, Tainer JA, Skehel JM, Groll M, Boulton SJ (2016) Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN. Mol Cell 64: 688-703

Stingele J, Schwarz MS, Bloemeke N, Wolf PG, Jentsch S (2014) A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair. Cell 158: 327-338