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Bartke, Till

Dr. Till Bartke

Institute of Functional Epigenetics (IFE), Helmholtz Zentrum Munich

Responsibilities

Project A27 - Cell Cycle-Dependent Regulation of the ORC-associated Protein LRWD1 by Phosphorylation of an Intrinsically Disordered Domain

Associated since 2017
Project leader since 2021

Contact

Institute of Functional Epigenetics
Helmholtz Zentrum München -
German Research Center for Environmental Health
Ingolstädter Landstr. 1
85764 Neuherberg

Phone: +49 89 3187 1553

Website: Institute of Functional Genetics, Helmholtz Zentrum München

Work group

Project A27

University degree

  • 1994 - 2000 Technical Biology, University of Stuttgart, Diploma in Biology (technically oriented), thesis supervisor: Dr. Harald Wajant (Institute of Cell Biology and Immunology/University of Stuttgart)

Advanced Academic Qualifications

  • 2005 Doctorate in Biology/Biochemistry, Max Plank Institute of Biochemistry/LMU Munich, supervisor: Prof. Dr. Stefan Jentsch

Postgraduate Professional Career

  • since 2017 Deputy Director, Institute of Functional Epigenetics, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
  • 2011 - 2017 Group Head, Chromatin Biochemistry Group, MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom
  • 2005 - 2011 Post-doctoral fellow, The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom

Honours and Awards

  • 2013 ERC Starting Grant ‘Regulation of Chromatin by Combinatorial DNA and Histone Modifications’ - Grant No. 309952/ROCCOMO (EUR 1.630.000.-)
  • 2011 - 2017 Honorary Lecturer/Lecturer at Imperial College London
  • 2011 Career Development Award at the MRC London Institute of Medical Sciences
  • 2009 Wellcome Trust/Cancer Research UK Gurdon Institute Poster Prize
  • 2006 Human Frontiers Science Program Organization (HFSP) Long Term Fellowship
  • 2005 European Molecular Biology Organization (EMBO) Long Term Fellowship
  • 2005 Max Planck Institute of Biochemistry Junior Research Award
  • 2004 Marie-Curie Actions Travel Award for ECDO Conference at Chania

Selected CRC-related publications

Nakamura K, Saredi G, Becker JR, Foster BM, Nguyen NV, Beyer T, Cesa LC, Faull PA, Lukauskas S, Frimurer T, Chapman RJ, Bartke T*, and Groth A*. (2019). H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nat. Cell Biol. 21, 311-318. DOI: 10.1038/s41556-019-0282-9. *Co-corresponding author.

Foster BM, Stolz P, Mulholland CB, Montoya A, Kramer H, Bultmann S, and Bartke T. (2018). Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin. Mol. Cell. 72, 739-752.e9. DOI: 10.1016/j.molcel.2018.09.028.

Makowski MM, Gräwe C, Nguyen NV, Foster BM, Bartke T*, and Vermeulen M*. (2018). Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry. Nat. Commun. 9, 1653. DOI: 10.1038/s41467-018-04084-0. *Co-corresponding author.

Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich E, and Bartke T. (2017). KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic Acids Res. 45, 1114-1129. DOI: 10.1093/nar/gkw979.

Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reveron-Gomez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel D, and Groth A. (2016). H4 K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. Nature 534, 714-718. DOI: 10.1038/nature18312.