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Cabianca, Daphne

Dr. Daphne Cabianca

Junior Research Group Leader, IFE Helmholtz Zentrum Munich


Project A28 - Characterization of the chromatin organization response to food deprivation in the intestine of C. elegans

Associated Member since 2020
Project leader since 2021


Environment and Nuclear Organization
Institute of Functional Epigenetics (IFE)
Helmholtz Zentrum München
Ingolstädter Landstr. 1
85764 Neuherberg

Website: Environment and Nuclear Organization

Work group

Project A28

University Degrees

  • 2004 - 2006 Master of science in Molecular Biology. “Regulation of alternative pre-mRNA splicing during oncogenesis in human cells”. Università degli Studi di Pavia, Italy. Laboratory of Dr. Biamonti, Institute of Molecular Genetics - National Research Council, Pavia, Italy.
  • 2001 - 2004 Bachelor of science in Biological Sciences. “Using minigenes in alternative pre-mRNA splicing assays”. Università degli Studi di Pavia, Pavia, Italy. Laboratory of Dr. Biamonti, Institute of Molecular Genetics - National Research Council, Pavia, Italy

Advanced Academic Qualifications

  • 2011 Doctorate in Molecular and Cellular Biology: “Characterization of the epigenetic mechanism at the basis of FSHD muscular dystrophy”, International PhD Program, Vita-Salute University San Raffaele, Milan (Italy) and Open University (UK), 31.08.2011, PhD supervisor: Dr. Davide Gabellini.

Professional Career

  • since 2020 Junior Group Leader, Institute of Functional Epigenetics, Helmholtz Zentrum, Munich, Germany
  • 2013 - 2020 Postdoctoral researcher, Susan Gasser laboratory, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
  • 2011 - 2013 Research fellow, Davide Gabellini laboratory, San Raffaele Scientific Institute, Milan, Italy
  • 2009 Eurasnet Laboratory Exchange fellow, Institute of Molecular Medicine, Lisbon, Portugal. Laboratory of Prof. Maria Carmo-Fonseca. “RNA and DNA fluorescence in situ hybridization”.
  • 2006 Visiting scientist, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, USA. Laboratory of Dr. Michael R. Green. “In vitro methods for studying RNA-protein interaction.”

Honours and Awards

  • 2015 - 2016 Marie Curie Intra European Fellowship (FP7).
  • 2014 EMBO Long Term Fellowship.
  • 2014 Human Frontiers Science Program Long-Term Fellowship (kindly declined).
  • 2012 “Nicolò Copernico Award” for excellence in biomedical sciences from the Università degli Studi di Ferrara, Italy.
  • 2010 - 2011 FacioScapuloHumeral Society Pre-doctoral Fellowship.
  • 2006 Short Term Mobility Fellowship, Italian National Research Council.


Selected publications

Cabianca DS, Muñoz-Jiménez C, Kalck V, Gaidatzis D, Padeken J, Seeber A, Askjaer P, and Gasser SM (2019) Active chromatin marks drive spatial sequestration of heterochromatin in differentiated cells. Nature 569 (7758):734-739.

Cabianca DS, Gasser SM (2016) Spatial segregation of heterochromatin: uncovering functionality in a multicellular organism. Nucleus 3; 7(3):301-7.

Cabianca DS, Casa V, Bodega B, Xynos A, Ginelli E, Tanaka Y, Gabellini D (2012) A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy. Cell 149:819-31.

Cabianca DS, Gabellini D (2010) The cell biology of disease: FSHD: copy number variations on the theme of muscular dystrophy. J Cell Biol 191:1049-60.

Gonzalez-Sandoval A, Towbin BD, Kalck V, Cabianca DS, Gaidatzis D, Hauer MH, Geng L, Wang L, Yang T, Wang X, Zhao K, Gasser SM (2015) Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos. Cell 3;163(6):1333-47.