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Hopfner, Karl-Peter

Prof. Dr. Karl-Peter Hopfner, ML

Gene Center, LMU Munich

Responsibilities

Project A06: Structure and Mechanism of the INO80 complex

Contact

Gene Center and
Department of Biochemistry
Ludwig-Maximilians-Universität München
Feodor-Lynen-Str. 25
81377 Munich
Germany

Phone: +49 (0)89 2180 - 76953
Fax: +49 (0)89 2180 - 76999

Website: Cellular Stress Response Machinery

Work group

Project A06

Curriculum Vitae

Academic Education

  • 1994-1997 PhD student with Robert Huber, Max-Planck-Institute for Biochemistry, Martinsried
  • 1994 Diploma in Biology; Advisor: Prof. Di Cera, University of St. Louis, USA
  • 1988-1993 Study of Biology, University of Regensburg

Advanced Professional Degrees

  • 1997 Promotion, Technische Universität München. Advisor: Prof. R. Huber, Max-Planck-Institute for Biochemistry, Martinsried

Positions Held

  • since 2016 Director, Department of Biochemistry, LMU Munich
  • since 2015 Director, Gene Center Munich
  • 2013-2015 Dean, Faculty of Chemistry and Pharmacy
  • since 2007 Full Professor, Department Biochemistry and Gene Center, Ludwig-Maximilians-Universität, München
  • 2005-2007 Associate Professor, Department Biochemistry and Gene Center, Ludwig-Maximilians-Universität, München
  • 2001-2005 Tenure-track Associate Professor, Department Biochemistry and Gene Center, Ludwig-Maximilians-Universität, München
  • 1999-2001 Postdoctoral fellow with John Tainer, The Scripps Research Institute, La Jolla, USA
  • 1998-1999 Postdoctoral fellow with Robert Huber, Max-Planck-Institute for Biochemistry, Martinsried
  • 1994-1997 PhD student in Robert Huber's laboratory, Max-Planck-Institute for Biochemistry, Martinsried 

Honours and Awards

  • 1991-1997 Fellow, Studienstiftung des Deutschen Volkes
  • 1997 Young Investigators Award, LEOPOLDINA, Halle
  • 2005 EMBO Young Investigator Award 2010 Elected Member of EMBO (European Molecular Biology Organisation)
  • 2011 m4 Award for personalized Medicine
  • 2012 ERC Advanced Grant
  • 2014 Elected Member of the German Academy of Sciences Leopoldina
  • 2014 Member of the Max-Planck-Society
  • 2016 Awarded Leibniz Prize

Editorial Activities

  •  since 2007 Editorial Board, Biophysical Chemistry 
  • since 2012 Editorial Board, Open Biology 

Other Professional Activities

  • 2005 Member, Max Planck Research School (IMPRS) ‘From Biology to Medicine’
  • 2006 Member, Munich Center for Integrated Protein Science Munich (CiPSM)
  • 2010 Co-Founder, SpectraMab GmBH 2011 Member of the Excellence Cluster CiPSM II
  • 2011 Member of the Graduate School ‘Quantitative Biosciences, Munich’
  • since 2012 Speaker, GRK1721
  • since 2013 Member of the Steering Committee, International Max-Planck Research School Molecular and Cellular Life Sciences
  • 2013-2014 Chair, Biochemistry Panel of the french ATIP-Avenir Program


Selected CRC project-related publications

Seifert F, Lammens K, Stöhr G, Kessler B, Hopfner KP (2016). Structural mechanism of ATPdependent DNA binding and DNA end bridging by eukaryotic Rad50. EMBO J 35, 759-72.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP (2015). ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Elife 4. pii: e10859.

Butryn A, Schuller JM, Stoehr G, Runge-Wollmann P, Förster F, Auble DT, Hopfner KP (2015).
Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1. Elife. doi: 10.7554/eLife.07432

Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP (2013). Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. Cell. 154, 1207-19.

Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP (2013). Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498, 332-7.