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Rupp, Ralph

Prof. Dr. Ralph Rupp

Biomedical Center - Molecular Biology, LMU Munich


Project A12: Regulation of embryonic cell plasticity by stage-specific histone modification profiles


Biomedical Center
Molecular Biology
Großhaderner Str. 9
82152 Plangegg-Martinsried

Phone: +49 (0)89 2180 -75438 or -75452

Website: Developmental Epigenetics

Work group

Project A12

Curriculum Vitae

Academic Education

  • 1979-1985 Studies in Biology at the Universities of Bremen, Cologne and Heidelberg
  • 1985 Diploma in Biology, University of Cologne (Supervisor: Prof. Dr. A.E. Sippel)

Advanced Professional Degrees

  • 1989 Promotion: Biology, Zentrum für Molekularbiologie der Universität Heidelberg (ZMBH), Ruprecht-Karls-Universität Heidelberg,  (Supervisor: Prof. Dr. A.E. Sippel)
  • 1998 Habilitation: Genetik, Eberhard-Karls-Universität Tübingen,  (Mentor: Prof. Dr. Gerd Jürgens)


Positions held

  • 1990 Postdoc at the ZMBH with Albrecht Sippel, Uni-Heidelberg
  • 1991-1993 Postdoc with Hal Weintraub, Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle-WA, USA
  • 1994-2000 Independent Group Leader at the Friedrich-Miescher-Institut, Max-Planck- Gesellschaft, Tübingen
  • since 2000 Professor for Molecular Biology at the Adolf-Butenandt-Institut, Faculty of Medicine, Ludwig-Maximilians-Universität München


  • 1991-1992 Ausbildungsstipendium der DFG

  • 1993 Postdoctoral Fellowship of the American Muscular Dystrophy Association

  • 1999-2003 Team Grant Coordinator for the Human Frontier Science Program

Selected CRC project-releated publications

Schuh L, Loos C, Pokrovsky D, Imhof A, Rupp RAW, Marr C. H4K20 methylation kinetics are differently regulated by dilution and demethylation in proliferating and cell-cycle arrested Xenopus embryos. ((December 16, 2020) Cell Systems 11, 1-10 .

Pokrovsky D, Forné I, Straub T, Imhof A, Rupp RAW. Mitotic activity shapes stage-specific histone modification profiles during Xenopus embryogenesis (2020). BioRxiv https://doi.org/10.1101/2020.08.04.200550

Bonnet J, Lindeboom RGH, Pokrovsky D, Stricker G, Celik MH, Rupp RAW, Gagneur J, Vermeulen M, Imhof A, Muller J. Quantification of Proteins and Histone Marks in Drosophila Embryos Reveals Stoichiometric Relationships Impacting Chromatin Regulation. (2019) Dev Cell 51: 632-644 e6.

Angerilli A, Smialowski P, Rupp RAW. The Xenopus animal cap transcriptome: building a mucociliary epithelium. (2018). Nucleic Acids Res 46: 8772-8787.