A33 - The role of chromatin in the establishment of inter-chromosomal DNA-DNA interactions
Inter-chromosomal interactions are essential for gene regulation in numerous biological systems including the mutually exclusive antigen expression in African Trypanosomes. Yet, very little is known about the mechanisms leading to the establishment and maintenance of such interactions. The goal of the work proposed here is to combine different live-cell imaging approaches and proteomics-based chromatin analyses to determine the molecular factors responsible for the establishment and maintenance of distinct inter-chromosomal DNA-DNA interactions in Trypanosoma brucei.
Prof. T. Nicolai Siegel, Ph.D.Experimental Parasitology, LMU Department of Veterinary Sciences +49 (0)89 2180 77098 |