A24 - Systematic screening for factors controlling heterochromatin formation in the mouse embryo and their role in modulating cellular plasticity
The project aims to identify and functional characterise the molecular players underlying heterochromatin formation at the beginning of mammalian development, using the mouse as a model system. We will achieve this through a dedicated screening for heterochromatin formation in the pre-implantation mouse embryo. The screening will be based on cell biology approaches to address chromatin function and high throughput imaging of chromatin factors in live embryos. We expect to deliver data that addresses the mechanisms and functional significance of heterochromatin remodelling during development as well as the interdependence of specific biochemical activities on chromatin in this process.
Mouse zygote stained with an anti-H3K9me3 antibody, highlighting the chromatin asymmetry between the parental genomes after fertilisation.
Available PhD and Postdoc positions, Scialdone Lab (pdf, 1 MB )