A16 - Quality control during chromatin assembly
PhD position available.
The structure of chromatin is continuously challenged through DNA metabolising processes. To provide access to the DNA, chromatin is frequently disassembled and reassembled. This assembly process is orchestrated by a complex system involving histone posttranslational modifying enzymes, molecular chaperones and multiple chromatin binding factors. Failures in the quality control system po-tentially result in loss of epigenetic information and cellular stress. In the past we have extensively described chromatin assembly in vitro and in vivo and now plan to study the changes upon various challenges such as the inhibition of the proteasome or histone modifying enzymes.
Figure: STRING network of proteins interacting with chromatin during in vitro assembly