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A20 - Understanding the role of histone short chain lysine acylations in the regulation of chromatin function

PhD position available.

Histone modifications can affect all chromatin dependent processes. Interestingly, the current set of characterised histone modifications is still incomplete. Recently histone proprionylation and butyrylation had been discovered as novel short chain lysine acylations. We have identified lysine 14 in histone H3 (H3K14) and lysine 16 in histone H4 (H4K16) as two important residues in the N-terminal histone tails that can be acetylated, proprionylated and butyrylated. Our aim is to unravel the function of these histone propionylations and butyrylations and compare these novel modifications with acetylation of the same residue.

 

Job description PhD position, Schneider Lab (pdf, 1 MB)

Schneider, Robert

Prof. Dr. Robert Schneider

Institute of Functional Epigenetics, Helmholtz Zentrum München