A17 - Dynamic changes of DNA modifications and chromatin states
DNA methylation has long been regarded as a rather stable epigenetic mark, but recent results show that this mark can be further modified by Tet dioxygenases and removed by base excision repair. DNA methylation itself is linked in many ways with repressive histone modifications and we could show that the major DNA methyltransferase (Dnmt1) specifically recognizes an H3K18 ubiquitination mark set by Uhrf1. We now want to investigate whether and to what extent alternative posttranslational modifications of histones and epigenetic factors contribute to the dynamic regulation of DNA methylation and gene expression in pluripotent and differentiated cells.
Dynamic changes of DNA modifications and chromatin states: Establishment, maintenance and dynamic changes of functional chromatin states