A21 - Involvement of histone methyl transferases in the anti-inflammatory actions of the Glucocorticoid Receptor
PhD and postdoc positions available (download job description, pdf 1 MB)
The Glucocorticoid Receptor (GR) is one of the most powerful anti-inflammatory drug targets, but the exact molecular mechanisms that lead to the repression of inflammatory genes are still unknown. By mass spectrometry, we have identified members of the transcriptional complex assembled by GR on inflammatory enhancers. This project aims to elucidate the role of H3K4 methyl transferases and the resulting histone methylation patterns during the silencing of inflammatory genes by GR. We will use genomic, genetic and biochemical assays to functionally characterize these novel candidates.
Histone methylation patterns of inflammatory cis-regulatory elements. ChIP-Sequencing data of the Ccl2 locus from mouse macrophages activated with LPS (lipopolysaccharide).